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People with a history of uveitis were more likely to experience recurrences of the potentially dangerous eye inflammation after vaccination against COVID-19, a retrospective population-based cohort study from South Korea found.

Of 473,934 vaccinated individuals with a prior case of uveitis, 16.8% developed it again within a year of vaccination, with an overall 21% elevated risk compared with the pre-vaccination period, Seong Joon Ahn, MD, PhD, of Hanyang University Seoul Hospital in South Korea, and colleagues reported in JAMA Ophthalmology.

"These findings suggest that there was an elevated risk of uveitis following COVID-19 vaccination, with the vaccine type and period mediating this risk," the authors wrote. "For individuals with a history of uveitis, clinicians should consider the potential risk of uveitis recurrence in vaccination strategies and clinical monitoring."

Although rare, uveitis remains a leading cause of legal blindness in the U.S. Head over to MedPage Today to read more about it.